Prerequisites:

  • Knowledge of applied statistical methods used in epidemiological studies is assumed (e.g. epidemiological study designs, multiple logistic regression). No prior knowledge of genetics, instrumental variable techniques, or Mendelian randomization is necessary.

Computing practicals:

  • Participants will gain most from the practicals if they have a working knowledge of either R or Stata, and bring a laptop with R or Stata loaded. For others, it is possible to share the practical sessions with those participants who have this experience.

Course objectives:

    After the course, participants should have sufficient knowledge to undertake their own Mendelian randomization analyses, to understand the assumptions on which causal inferences are based, and to critically appraise published studies using Mendelian randomization.

Timetable:

Day 1

9.30   Registration and coffee
10.00   Welcome
10.15 Session 1
Motivation and introduction (SB)
10.45 Session 2 Estimation using individual-level data (JB)
11.15   Coffee
11.45 Session 3
Some examples of Mendelian randomization (RS)
12.15 Practical 1 Mendelian randomization using individual-level data
13.15   Practical wrap-up (JR)
13.30   Lunch
14.30 Session 4 Summarized data and two-sample Mendelian randomization (JB)
15.00 Practical 2
Mendelian randomization using summarized data
16.00   Practical wrap-up (JR)
16.15   Tea
16.45 Session 5
Assumptions of Mendelian randomization (SB)
17.15 Session 6
Mendelian randomization in practice (RS)
17.45   End of day 1
Evening   Course Dinner in Local Restaurant

 

Day 2

9.00 Session 7
Robust methods with summarized data (JB)
9.30 Practical 3 Critical appraisal of published MR studies (SB)
10.45   Coffee
11.15 Session 8 Issues in estimation (SB)
11.45 Session 9
Weak instruments and allele scores (JR)
12.15 Practical 4 Robust methods and sensitivity analyses with summarized data
13.15   Practical wrap up (JR)
13.30   Lunch
14.30 Session 10
Interpretation of Mendelian randomization estimates (SB)
15.00 Session 11
Mendelian randomization for drug development (RS)
15.30   Tea
16.00   Participants' examples / questions
17.00   Concluding remarks